Why is the Cold Agglutinin Reactive in Cold?

Cold agglutinin disease.

Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies for accurate diagnosis and treatment. Retrospective analysis identified 89 patients from our institution with cold...

Detection of Cold Agglutinin with Cross-Reactive Idiotype Produced by Pneumonie Patients

Why is the centromere so cold?

Chromosomes are known to contain local hot and cold spots that undergo quite different rates of meiotic recombination. The question of why such regional variation in recombination rates exists on chromosomes holds a strange mix of intrigue and frustration for geneticists. One of the human chromosomes that has been carefully studied over the years in this regard is the X chromosome. These studie...

Cold Agglutinin Disease; A Laboratory Challenge

INTRODUCTION Autoimmune haemolytic anemia (AIHA) is a complex process characterized by an immune reaction against red blood cell self-antigens. The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...

How I manage cold agglutinin disease.

Primary chronic cold agglutinin disease (CAD) is a clonal lymphoproliferative disorder accounting for 13-15% of autoimmune haemolytic anaemias. Significant advances have been made in treatment, which was largely unsuccessful until recently. The essential clinical, immunological and pathological features are reviewed, focusing on their relevance for therapy. Non-pharmacological management still ...